How MyTrial matching works

Eligibility criteria are written for regulators and research coordinators, not for the people they describe. “ECOG ≤ 1,” “adequate organ function,” “no prior exposure to anti-HER2 therapy” — real criteria, from real listings, that most patients were never meant to parse alone. Matching is MyTrial reading that fine print for you.

What the AI reads

Two things. First, the public record: the eligibility criteria, locations, and status of recruiting trials registered on ClinicalTrials.gov. Second, what you've chosen to share — the conditions, medications, and history in your Health Passport. The more complete your passport, the more precisely criteria can be checked against your situation; what you don't share simply isn't used.

What you see

Each match shows the criteria in plain language and the reasons the trial appears to fit — criterion by criterion, mapped to what you've shared. Where your information doesn't answer a criterion, we say so. Uncertainty stays visible: an unknown is shown as an unknown, never silently filled in or guessed at.

What the AI never does

It never diagnoses you, never gives medical advice, and never decides for you. Every AI-generated element on MyTrial is labeled as such, and your health information is never sold. How our agents work, what they're allowed to do, and how their reasoning is audited is documented openly on our trust and AI transparency pages — the same standard we hold for every AI feature we ship.

If you want to go deeper, the “How our AI works” page walks through the agent mesh itself — what each agent does, and the rules every one of them operates under.